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Part of the Oxford American Rheumatology Library, this concise, authoritative pocketbook provides the most up-to-date information on the diagnosis, treatment and management of lupus. The volume describes the pathophysiology of the condition, diagnostic strategies and tools, and current and emerging therapeutic options, focusing on direct clinical applications for busy healthcare professionals. One million people in the United States suffer from systemic lupus erythematosus (SLE or lupus), a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often damages the heart, joints, skin, lungs, blood vessels, liver, kidneys and nervous system. The course of the disease is unpredictable, with periods of illness alternating with remission. It can be treated symptomatically, mainly with corticosteroids and immunosuppressants, though there is currently no cure. Several promising new treatments, however, are in late-stage clinical trials. Lupus is one of several diseases known as the 'great imitator' because its symptoms vary so widely and it often mimics or is mistaken for other illnesses, and because the symptoms come and go unpredictably. As a result, patients present with varied symptoms to different practitioners and diagnosis can be elusive, with patients sometimes suffering unexplained symptoms and untreated lupus for years. Hence, a practical guide to the diagnosis and treatment of lupus would be valuable to an array of clinicians and may help expedite earlier diagnosis and better patient care. The target audience is rheumatologists in training and primary care physicians who care for lupus patients and allied health professionals who assist in their management. The book will fulfill a need for a concise, practical guide to Lupus for clinicians that distills the principal features of this complicated, often misunderstood disorder. Dr. Daniel J. Wallace is one of the world's leading authorities on the disorder, an eminent clinician who has treated over 2,000 lupus patients, the largest such practice in America. He is the author of another Oxford book--The Lupus Book, and the editor of the premier authoritative lupus textbook, Dubois' Lupus Erythematosus.

Lupus erythematosus. --- Cutaneous lupus erythematosus --- Skin --- Diseases

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Lupus is a disorder in which the body's immune system attacks itself, culminating in disease which can affect multiple organs. This new edition reflects major developments in our understanding of the causes of lupus and helps patients understand lupus with a view to self-management.

Systemic lupus erythematosus. --- Autoimmune diseases. --- Autoimmunologic diseases --- Autoimmunity --- Immunologic diseases --- Libman-Sacks disease --- Lupus (Systemic lupus erythematosus) --- Lupus erythematosus, Systemic --- Lupus erythematosus disseminatus --- SLE (Disease) --- Autoimmune diseases --- Blood-vessels --- Collagen diseases --- Skin --- Diseases --- Lupus erythematosus --- Lupus erythematodes --- Systemic lupus erythematosus

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"Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage Discusses the latest treatment options on disease modifying or disease controlling agents Provides 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment"--

Systemic lupus erythematosus. --- Lupus Erythematosus, Systemic --- Lupus Erythematosus, Systemic. --- Biomarkers. --- Comorbidity. --- diagnosis. --- physiopathology. --- therapy.

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Systemic lupus erythematosus. --- Libman-Sacks disease --- Lupus (Systemic lupus erythematosus) --- Lupus erythematosus, Systemic --- Lupus erythematosus disseminatus --- SLE (Disease) --- Autoimmune diseases --- Blood-vessels --- Collagen diseases --- Skin --- Diseases

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Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. * Highly illustrated and in full color throughout * Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment * Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice.

Systemic lupus erythematosus. --- Lupus Erythematosus, Cutaneous --- Lupus Erythematosus, Systemic --- Antiphospholipid Syndrome --- Lupus Erythematosus, Systemic. --- Libman-Sacks Disease --- Lupus Erythematosus Disseminatus --- Systemic Lupus Erythematosus --- Disease, Libman-Sacks --- Libman Sacks Disease --- Libman-Sacks disease --- Lupus (Systemic lupus erythematosus) --- Lupus erythematosus, Systemic --- Lupus erythematosus disseminatus --- SLE (Disease) --- Autoimmune diseases --- Blood-vessels --- Collagen diseases --- Skin --- Diseases